ea0090oc8.2 | Oral Communications 8: Calcium and Bone | ECE2023
Ravel Guillaume
, Delale Thomas
, Milano Stephane
, Chirat Sophie
, Verset Michael
, Latronico Emilie
, Allas Soraya
, Culler Michael D.
Eneboparatide (AZP-3601) is a novel, synthetic, 36-amino-acid peptide agonist of the parathyroid hormone type 1 receptor (PTHR1), with potent selectivity for the R0 conformation. This results in prolonged calcemic responses, while having a short circulating half-life. Eneboparatide is being developed for the treatment of chronic hypoparathyroidism (cHP). Studies in hypoparathyroid animal models and, most recently, in hypoparathyroid patients, have demonstrated that eneboparati...